The system is capable of delivering 300,000* emails per hour (2Kb size in Fast mode) using a 1.6 GHz P4 machine with 1Gb of memory on a 5 Mbps bandwidth connection. In Personalized mode, delivery rate is 30,000 emails per hour.
If you plan to send very large mailings, keep in mind that bounces, tracking, and un-subscription requests still need to be processed by the server. The effective workload becomes 3-4 million emails per day.
Another factor to consider is the source of your email lists. If a list contains unsolicited emails, you run the risk of your connection being shut down by your provider and the IP address of the server being blacklisted. The best way to avoid this is to make sure that your lists are qualified lists (Opt-ins) where users have asked to receive this type of email.
The server will require a permanent connection to the Internet on a static IP address, to properly handle un-subscriptions, bounces, and campaign tracking.
* Note: Actual performance is dependent on the hardware used, Internet connection, and quality of the list.